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Pregabalin: Concomitant administration of pregabalin with CNS depressant drugs, including buspirone, can potentiate the CNS effects of either agent. Baclofen: Concomitant use of skeletal muscle relaxants with buspirone can result in additive CNS depression. Dosage adjustments of either or both medications may be necessary. Sontheimer DL, Ables AZ March 2001. "Is imipramine or buspirone treatment effective in patients wishing to discontinue long-term benzodiazepine use? The 16 buspirone outcomes included 2 elective abortions, 1 intrauterine death, 12 normal term babies, and 1 newborn with cystic fibrosis. Because the available data are too limited to be conclusive, buspirone should be used during pregnancy only if clearly needed. The effects of buspirone during labor and delivery are unknown. eklov.info retin-a

Side effects of buspirone

Pramipexole: The combination of buspirone and other CNS depressants, such as pramipexole, can increase the risk for sedation. Brexpiprazole: The combination of buspirone and CNS depressants like the antipsychotics can increase the risk for drowsiness, sedation, and dizziness. Aspirin, ASA: In vitro studies showed that therapeutic levels of aspirin, ASA increased the plasma concentrations of free buspirone by 23% through plasma protein binding displacement. In vivo interaction studies with these drugs have not been performed.

Reviews for buspirone

Acetaminophen; Butalbital; Caffeine: Substances that are potent inducers of hepatic cytochrome P450 isoenzyme CYP3A4, such as barbiturates, may increase the rate of buspirone metabolism. If a patient has been titrated to a stable dosage on buspirone, a dose adjustment of buspirone may be necessary to maintain anxiolytic effect. There is also a risk of additive CNS depression when buspirone is given concomitantly with barbiturates. Ribociclib; Letrozole: Use caution if coadministration of ribociclib with buspirone is necessary, as the systemic exposure of buspirone may be increased resulting in an increase in buspirone-related adverse reactions. Consider starting with a low dose of buspirone with subsequent dose adjustments based on clinical assessment. Ribociclib is a moderate CYP3A4 inhibitor and buspirone is a CYP3A4 substrate.

Before taking buspirone

Lopinavir; Ritonavir: When buspirone is administered with a potent inhibitor of CYP3A4 like ritonavir, a low dose of buspirone used cautiously is recommended. Some patients receiving drugs that are potent inhibitors of CYP3A4 with buspirone have reported lightheadedness, asthenia, dizziness, and drowsiness. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist.



Buspirone brand names

Serotonin syndrome, in its most severe form, can resemble neuroleptic malignant syndrome. Several cases of elevated blood pressure have been reported in patients in whom buspirone was added to a non-selective traditional MAO-inhibitor regimen. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Activated charcoal is believed to be an effective treatment for overdose, provided the patient is treated promptly. It may harm them and it is against the law. HT 1A receptors. In accordance, an found that buspirone dose-dependently decreases levels, while increasing and levels. It is thought that the main effects of buspirone are mediated via its interaction with the 5-HT 1A receptor. Some of its effects may be mediated via release secondary to 5-HT 1A receptor agonism. Verapamil: Coadministration of buspirone with verapamil substantially increases the plasma concentrations of buspirone by about three-fold. The mechanism is probably related to the inhibition of CYP3A4 by verapamil. Buspirone dose adjustment may be necessary and should be based on clinical assessment. Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets Mixed Salts of a Single Entity Amphetamine Product for long-term use has not been systematically evaluated in controlled trials. They are available in bottles of 100 tablets NDC 57844-117-01.



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Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. Carbetapentane; Chlorpheniramine: Drowsiness has been reported during administration of carbetapentane. An enhanced CNS depressant effect may occur when carbetapentane is combined with other CNS depressants including buspirone. The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. Diazepam: It is common for patients to overlap anxiety treatment when switching from benzodiazepines to buspirone. Buspirone has a slow onset of action and the drug will not block the withdrawal syndrome often seen with cessation of benzodiazepine therapy in those with benzodiazepine dependence. Therefore, before starting therapy with buspirone, withdraw patients gradually from the benzodiazepine. Alternatively, conversion to buspirone therapy may require treatment overlap to allow for the downward titration of the benzodiazepine while buspirone takes effect. Meclizine: The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Dexamethasone: Potent inducers of hepatic cytochrome P450 3A4, such as dexamethasone, may increase the rate of buspirone metabolism. Acetaminophen; Codeine: Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of codeine, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. Acetaminophen; Propoxyphene: Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of propoxyphene, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. Chlorzoxazone: Concomitant use of skeletal muscle relaxants with buspirone can result in additive CNS depression. Dosage adjustments of either or both medications may be necessary. Chlordiazepoxide: It is common for patients to overlap anxiety treatment when switching from benzodiazepines to buspirone. Buspirone has a slow onset of action and the drug will not block the withdrawal syndrome often seen with cessation of benzodiazepine therapy in those with benzodiazepine dependence. Therefore, before starting therapy with buspirone, withdraw patients gradually from the benzodiazepine. Alternatively, conversion to buspirone therapy may require treatment overlap to allow for the downward titration of the benzodiazepine while buspirone takes effect. Isocarboxazid: Concomitant use of MAOIs and buspirone is contraindicated because several cases of elevated blood pressure have been reported in patients taking MAO inhibitors who were then given buspirone HCL. A 10-day interval after discontinuing isocarboxazid is recommended before initiating buspirone treatment. Nortriptyline: Because of the potential risk and severity of serotonin syndrome, caution should be observed when administering tricyclic antidepressants TCAs with other drugs that have serotonergic properties such as buspirone. Buspirone increases the sensitivity of postsynaptic serotonin receptors and TCAs inhibit the reuptake of serotonin. PO twice daily is recommended initially. Subsequent dosage adjustments should be based on clinical response. amoxil



Buspirone uses

Division of Teva Pharmaceuticals USA, Inc. Narcolepsy seldom occurs in children under 12 years of age; however, when it does, dextroamphetamine sulfate may be used. The suggested initial dose for patients aged 6 to 12 is 5 mg daily; daily dose may be raised in increments of 5 mg at weekly intervals until optimal response is obtained. In patients 12 years of age and older, start with 10 mg daily; daily dosage may be raised in increments of 10 mg at weekly intervals until optimal response is obtained. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. While both fluoxetine and carbamazepine were present in the breast milk and infant serum samples, buspirone was undetectable. The infant's neurological exam and electroencephalography were normal. The authors were unable to determine the cause of the seizure-like activity. Although the American Academy of Pediatrics AAP does not specifically address the use of buspirone during breast-feeding, the AAP cautions that psychotropic medications affect neurotransmitter function in the developing central nervous system, and therefore, the accurate prediction of long-term adverse effects may not be possible. Due to individual variability in the response to buspirone and other anxiolytics, it may be prudent to continue the existing regimen if ongoing treatment is deemed necessary during breast-feeding. However, because a pooled analysis found that maternal use of paroxetine usually produced undetectable or low drug concentrations in infant serum, this agent may be preferred when initiating therapy for generalized anxiety disorder in a breast-feeding mother. A short-acting benzodiazepine such as lorazepam may be beneficial when immediate relief of anxiety symptoms is required, although the AAP classifies many benzodiazepines as drugs for which the effects on a nursing infant are unknown but may be of concern, particularly with prolonged exposure. If any benzodiazepine is used by a breast-feeding mother, the infant should be monitored for adverse effects, such as sedation. Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. If a breast-feeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA. This list is not complete. Other drugs may interact with buspirone, including prescription, over-the-counter, vitamin, and herbal products. Not all possible interactions are listed in this medication guide. International Review of Neurobiology found that buspirone may be an effective treatment for Tourette syndrome, a brain disorder that causes people to make uncontrolled and repetitive movements and sounds tics. The symptoms must not be better accounted for by another mental disorder. Compare Buspirone Prices - GoodRx", "side_effects_page": "Buspirone Side Effects, Information and Pricing - GoodRx", "medicare_seo_page": "Buspirone Medicare Coverage and Co-Pay Details - GoodRx", "price_page": "Buspirone Prices and Buspirone Coupons - GoodRx", "info_page": "What is Buspirone? While using buspirone, you may need frequent blood tests at your doctor's office. Several hydroxylated derivatives and a pharmacologically active metabolite, 1-pyrimidinylpiperazine 1-PP are produced. In animal models predictive of anxiolytic potential, 1-PP has about one quarter of the activity of buspirone, but is present in up to 20-fold greater amounts. Aprepitant, Fosaprepitant: Use caution if buspirone and aprepitant, fosaprepitant are used concurrently and monitor for an increase in buspirone-related adverse effects for several days after administration of a multi-day aprepitant regimen. In vitro, buspirone is a CYP3A4 substrate. Chiodera P, Volpi R, Capretti L, Caffarri G, Magotti MG, Coiro V April 1996. "Different effects of the serotonergic agonists buspirone and sumatriptan on the posterior pituitary hormonal responses to hypoglycemia in humans". Neuropeptides. Tetrabenazine: Concurrent use of tetrabenazine and drugs that can cause CNS depression, such as buspirone, can increase both the frequency and the intensity of adverse effects such as drowsiness, sedation, dizziness, and orthostatic hypotension. price biaxin south africa biaxin



What happens if I overdose Buspar?

Lurasidone: The combination of buspirone and CNS depressants like the antipsychotics can increase the risk for drowsiness, sedation, and dizziness. The following enumeration by organ system describes events in terms of their relative frequency of reporting in this data base. Events of major clinical importance are also described in the section. Which drugs or supplements interact with buspirone? Mephobarbital: Substances that are potent inducers of hepatic cytochrome P450 isoenzyme CYP3A4, such as barbiturates, may increase the rate of buspirone metabolism. If a patient has been titrated to a stable dosage on buspirone, a dose adjustment of buspirone may be necessary to maintain anxiolytic effect. There is also a risk of additive CNS depression when buspirone is given concomitantly with barbiturates. Squibb Company September, 2007. Alfentanil: Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of alfentanil, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use is imperative, reduce the dose of one or both drugs if clinically indicated. This drug may make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid beverages. Midazolam: It is common for patients to overlap anxiety treatment when switching from benzodiazepines to buspirone. Buspirone has a slow onset of action and the drug will not block the withdrawal syndrome often seen with cessation of benzodiazepine therapy in those with benzodiazepine dependence. Therefore, before starting therapy with buspirone, withdraw patients gradually from the benzodiazepine. Alternatively, conversion to buspirone therapy may require treatment overlap to allow for the downward titration of the benzodiazepine while buspirone takes effect. Tell your doctor if you or your child are pregnant, planning to become pregnant, or breastfeeding. Azelastine; Fluticasone: An enhanced CNS depressant effect may occur when azelastine is combined with other CNS depressants including buspirone. generic prometrium when will it be available



Malhotra S, Santosh PJ April 1998

Each tablet contains 10 mg buspirone hydrochloride. Allen LE, Ferguson HC, Kissel JW May 1972. "Psychosedative agents. 2. 8-4-Substituted 1-piperazinylalkyl-8-azaspiro4. Thus, dose increases and repeated dosing may lead to somewhat higher blood levels of unchanged buspirone than would be predicted from results of single-dose studies. Carbetapentane; Pyrilamine: Drowsiness has been reported during administration of carbetapentane. An enhanced CNS depressant effect may occur when carbetapentane is combined with other CNS depressants including buspirone. The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. Isoniazid, INH; Rifampin: Substances that are potent inducers of hepatic cytochrome P450 isoenzyme CYP3A4, such as rifampin, may increase the rate of buspirone metabolism. In a study of healthy volunteers, co-administration of buspirone with rifampin decreased the plasma concentrations 83. Carbinoxamine; Hydrocodone; Pseudoephedrine: Concomitant use of hydrocodone with other central nervous system depressants, such as buspirone, can potentiate the effects of hydrocodone and may lead to additive CNS or respiratory depression. If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. Maprotiline: CNS depressants should be combined cautiously with maprotiline because they could cause additive depressant effects and possible respiratory depression or hypotension. Desipramine: Because of the potential risk and severity of serotonin syndrome, caution should be observed when administering tricyclic antidepressants TCAs with other drugs that have serotonergic properties such as buspirone. Buspirone increases the sensitivity of postsynaptic serotonin receptors and TCAs inhibit the reuptake of serotonin. Alan F. Schatzberg; Charles B. Nemeroff 2009. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. Capsaicin; Metaxalone: Concomitant use of skeletal muscle relaxants with buspirone can result in additive CNS depression. Dosage adjustments of either or both medications may be necessary. Mohammadi MR, Hafezi P, Galeiha A, Hajiaghaee R, Akhondzadeh S November 2012. Amphetamines have been extensively abused. Tolerance, extreme psychological dependence, and severe social disability have occurred. There are reports of patients who have increased the dosage to levels many times higher than recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. Manifestations of chronic intoxication with amphetamines include severe dermatoses, marked insomnia, irritability, hyperactivity, and personality changes. The most severe manifestation of chronic intoxication is psychosis, often clinically indistinguishable from schizophrenia.



About buspirone

Buspirone hydrochloride tablets are indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. Erythromycin; Sulfisoxazole: Concomitant administration of erythromycin with buspirone may result in significant increases in buspirone AUC; the mechanism is probably reduced buspirone metabolism via CYP3A4. If the two drugs are to be used in combination, a low dose of buspirone is recommended. Subsequent dose adjustment of either drug should be based on clinical assessment. Retrieved 25 June 2014. Remifentanil: Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of remifentnil, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use is imperative, reduce the dose of one or both drugs if clinically indicated. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Nelfinavir: When buspirone is administered with an inhibitor of CYP3A4 like nelfinavir, a lower dose of buspirone is recommended. Dose adjustment of either drug should be based on clinical assessment. What happens if I overdose Buspar? Store at room temperature away from moisture, heat, and light. Clozapine: The combination of buspirone and CNS depressants like the antipsychotics can increase the risk for drowsiness, sedation, and dizziness. Grapefruit juice: Grapefruit juice has been reported to significantly increase buspirone peak concentrations and AUC, probably through the inhibition of gut-wall CYP3A4 isoenzyme metabolism. There may be great variation in the significance of this effect among individuals. Subjective drowsiness and other side effects of buspirone may be increased with grapefruit juice ingestion. Patients receiving buspirone should be advised to avoid drinking large amounts of grapefruit juice. Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by buspirone. Codeine; Guaifenesin: Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of codeine, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. shoppers drug mart alesse price



PO twice daily is recommended

Perampanel: Co-administration of perampanel with CNS depressants, including ethanol, may increase CNS depression. The combination of perampanel particularly at high doses with ethanol has led to decreased mental alertness and ability to perform complex tasks such as driving as well as increased levels of anger, confusion, and depression; similar reactions should be expected with concomitant use of other CNS depressants, such as buspirone. They are available in bottles of 100 tablets NDC 57844-112-01. Zyvox an that is also an MAO inhibitor. These measures will help protect the environment. It should not be used to treat angina when it occurs. Use other medications such as placed under the to relieve an angina attack as directed by your doctor. Consult your doctor or pharmacist for details. Ziprasidone: The combination of buspirone and CNS depressants like the antipsychotics can increase the risk for drowsiness, sedation, and dizziness. Morton; Judith M. Hall 6 December 2012. Loxapine: The combination of buspirone and CNS depressants like the antipsychotics can increase the risk for sedation. order cheapest meridia shop canada meridia



Buspirone consumer information

It is against the law. Butorphanol: Concomitant use of butorphanol with other CNS depressants, such as buspirone, can potentiate the effects of butorphanol on respiratory depression, CNS depression, and sedation. Carbetapentane; Diphenhydramine; Phenylephrine: Drowsiness has been reported during administration of carbetapentane. An enhanced CNS depressant effect may occur when carbetapentane is combined with other CNS depressants including buspirone. The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. Buspirone may cause drowsiness and confusion. Hydrocodone; Ibuprofen: Concomitant use of hydrocodone with other central nervous system depressants, such as buspirone, can potentiate the effects of hydrocodone and may lead to additive CNS or respiratory depression. If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. It may take up to a month or more to get the full effect of this medication. Digoxin: Buspirone can displace digoxin from plasma proteins, but the clinical significance of this effect has yet to be determined. Nalbuphine: Concomitant use of nalbuphine with other CNS depressants, such as buspirone, can potentiate the effects of nalbuphine on respiratory depression, CNS depression, and sedation. Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with amphetamine or dextroamphetamine and should counsel them in its appropriate use. During or within 14 days following the administration of monoamine oxidase inhibitors hypertensive crises may result. valsartan



How to take buspirone

Danazol: Danazol is a CYP3A4 inhibitor and can decrease the hepatic metabolism of buspirone, a CYP3A4 substrate. Sporanox nefazodone Serzone and rifampin. There are no adequate studies of Buspar in pregnant women and it is not known if Buspar is secreted in human breast milk. Use during pregnancy is not recommended unless the potential benefit outweighs the potential unknown risk to the fetus. It is unknown if Buspar passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding. PO twice daily, is recommended initially. Subsequent dosage adjustments should be based on clinical response. Not all package sizes may be marketed. Tramadol: Tramadol can cause additive CNS depression when used with other agents that are CNS depressants including buspirone. Darunavir: The plasma concentrations of buspirone may be elevated when administered concurrently with darunavir. Close clinical monitoring is recommended during coadministration; buspirone dose reductions may be required. Predictions regarding this interaction can be made based on the metabolic pathways of these drugs. Darunavir is an inhibitor of CYP3A4, an isoenzyme responsible for the metabolism of buspirone. These drugs used in combination may result in elevated buspirone plasma concentrations, causing an increased risk for buspirone-related adverse events.



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The American Journal of Medicine


Buspirone dosing information

Zafirlukast: In vitro data indicate that zafirlukast inhibits the CYP2C9 and CYP3A4 isoenzymes at concentrations close to the clinically achieved total plasma concentrations. Until more clinical data are available, zafirlukast should be used cautiously in patients stabilized on drugs metabolized by CYP3A4, such as buspirone. Examples of CYP2D6 Inhibitors include paroxetine and fluoxetine also serotonergic drugs quinidine, ritonavir. Cardiovascular effects include arrhythmias, hypertension or hypotension and circulatory collapse. Temazepam: It is common for patients to overlap anxiety treatment when switching from benzodiazepines to buspirone. Buspirone has a slow onset of action and the drug will not block the withdrawal syndrome often seen with cessation of benzodiazepine therapy in those with benzodiazepine dependence. Therefore, before starting therapy with buspirone, withdraw patients gradually from the benzodiazepine. Alternatively, conversion to buspirone therapy may require treatment overlap to allow for the downward titration of the benzodiazepine while buspirone takes effect. cheap fexofenadine capsules

Take the medicine pack with you

If you have been switched to buspirone from another anxiety medication, you may need to slowly decrease your dose of the other medication rather than stopping suddenly. Some anxiety medications can cause withdrawal symptoms when you stop taking them suddenly after long-term use. Basics, Side Effects, Interactions, and Dosage tabs. The information within the Reviews and FAQ tabs is proprietary to Everyday Health. Foods and beverages high in tyramine should be avoided while you are taking this medication and for at least 2 weeks after you stop using this medication. Gammans RE, Mayol RF, LaBudde JA 1986. "Metabolism and disposition of buspirone". Am. J. Med. buy triamcinolone online visa uk

After first opening use within1 year

Read the Guide and, if available, the Patient Information Leaflet provided by your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist. The tablet can be divided into equal doses. Impotence, changes in libido, frequent or prolonged erections. prozac

Buspirone warnings

Cariprazine: The combination of buspirone and CNS depressants like the antipsychotics can increase the risk for drowsiness, sedation, and dizziness. Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine: The combination of buspirone and other CNS depressants, such as sedating h1-blockers, can increase the risk for sedation. Zaleplon: The combination of buspirone and other CNS depressants can increase the risk for sedation.

Switching from one of these drugs to buspirone will not prevent a withdrawal reaction because buspirone does not act like these other medications. Instead, you have to taper down the dose of the drugs gradually. Cobicistat: The plasma concentrations of buspirone may be elevated when administered concurrently with cobicistat. Close clinical monitoring is recommended during coadministration; buspirone dose reductions may be required. Predictions regarding this interaction can be made based on the metabolic pathways of these drugs. Cobicistat is an inhibitor of CYP3A4, an isoenzyme responsible for the metabolism of buspirone. These drugs used in combination may result in elevated buspirone plasma concentrations, causing an increased risk for buspirone-related adverse events.

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